Metabolic syndrome (MetS) encompasses a cluster of cardiometabolic risk factors such as central obesity, low levels of HDL-cholesterol (HDL-C), hypertriglyceridemia, hypertension, and hyperglycemia. Identifying children and adolescents at risk of developing MetS early on is crucial, as they are highly susceptible to developing type 2 diabetes (T2D) and cardiovascular disease (CVD) later in life Consanguinity (marriages between first or second cousins) can contribute to multiple factors associated with the disease. Obesity and insulin resistance are contributing factors to MetS in children and adolescents, with obesity being the primary factor that worsens with increased body weight. In Pakistan, several studies have addressed MetS and its associated complications, including the issue of screening affordability in children. Initiatives focusing on balanced dietary advice and interventions to identify alarming biomarkers of MetS have been implemented.